Treating Castleman’s Disease

Treatment options for Castleman’s Disease vary by type.

Treatment of Unicentric Castleman’s Disease (UCD)

In UCD, surgical excision of the affected nodes is curative in approximately 95% of patients. Nodal masses that are attached to vital tissues may not be amenable to surgical removal. In these cases, radiotherapy may be considered.1

Because UCD has been reported to recur as long as 11 years after incomplete resection, long-term follow-up is warranted for patients who have been diagnosed with and treated for UCD.1

Treatment of Multicentric Castleman’s Disease (MCD)

Because of the diffuse nature of the disease and severity of systemic symptoms, MCD requires a different approach to treatment. There are no guidelines or treatment protocols defining the use of specific therapies for MCD; however, various treatment options are currently used by physicians such as corticosteroids, chemotherapy, radiation, and immunotherapies.1,2

  1. van Rhee F, Stone K, Szmania S, Barlogie B, Singh Z. Castleman disease in the 21st century: an update on diagnosis, assessment, and therapy. Clin Adv Hematol Oncol. 2010;8(7):486-498.
  2. Bonekamp D, Horton KM, Hruban RH, Fishman EK. Castleman disease: the great mimic. Radiographics. 2011;31(6):1793-1807.